Abstract: In this talk, I shall introduce the notion of polynomials with Lorentzian signature. This class is a generalization to the remarkable class of Lorentzian polynomials. The hyperbolic polynomials and conic polynomials are shown to be polynomials with Lorentzian signature. Using the notion of polynomials with Lorentzian signature I shall describe how to compute the permanents of a special class of nonsingular matrices via hyperbolic programming. The nonsingular $k$ locally singular matrices are contained in the  special class of nonsingular matrices for which computing the permanents can be done via hyperbolic programming.