##### Department of Mathematics,

University of California San Diego

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### Quantitative-Biology Faculty Candidate Seminar

## Hyun Youk

#### University of California, San Francisco

## Deconstructing and Encoding Emergent Behaviors of Cells

##### Abstract:

Can we describe complex behaviors of living systems, arising from millions of intracellular and intercellular interactions, in simple mathematical models without dizzying number of parameters? For two examples, I combine simple models and experiments to show that this is possible. First, I reduce the complexity of yeast cell's growth from food (glucose) consumption to a phenomenological model with two parameters - Cell's perception of and uptake rate of glucose. Second, I show that a cell tunes how much it "talks" to itself versus to its neighbors by secreting and sensing just one signaling molecule. Encoding who talks to whom, a population of "secrete-and-sense cell" realizes a rich repertoire of complex behaviors.

Host: David Kleinfeld

### January 27, 2014

### 12:00 PM

### NSB Auditorium 1205

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