##### Department of Mathematics,

University of California San Diego

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### Postdoc Seminar

## Shuang Liu

#### UCSD

## Level set simulations of cell polarity and movement

##### Abstract:

We develop an efficient and accurate level set method to study numerically a crawling eukaryotic cell using a minimal model. This model describes the cell polarity and movement using a reaction-diffusion system coupled with a sharp-interface model.

We employ an efficient finite difference method for the reaction-diffusion equations with no-flux boundary conditions. This results in a symmetric positive definite system, which can be solved by the conjugate gradient method accelerated by preconditioners. To track the long-time dynamics, we employ techniques of the moving computational window to keep the efficiency. Our level-set simulations capture well the cell crawling, the straight line trajectory, the circular trajectory, and other features.

Our efficient and accurate computational techniques can be extended to a broad class of biochemical descriptions of cell motility, for which problems are posed on moving domains with complex geometry and fast simulations are very important. This is a joint work with Li-Tien Cheng and Bo Li.

### May 19, 2022

### 3:15 PM

AP&M B402A

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